Cannabidiol (CBD) information
The hemp plant, domesticated 6000 years ago in China, produces more than 400 organic compounds. The two main groups of molecules with bioactive properties found in hemp are terpenes and cannabinoids – CBD being a molecule of the latter.
Cannabinoids are compounds that can influence functioning of the human nervous system. The hemp plant biosynthesizes more than 60 of them. The major cannabinoids are THC, CBD, CBG and they differ in their chemical structure and action.
Cannabidiol, or CBD, is one of the most abundant cannabinoids found in hemp. CBD is thought to have many therapeutic applications and helps to unwind. While beneficial for wellbeing, CBD doesn’t have the psychoactive properties of its more famous cousin THC, and should not be confused for THC.
DOES CBD GET YOU HIGH?
No, CBD will not get you high. CBD is non-psychoactive. In other words, after using CBD oil, you will not experience significant changes in mood, awareness or state of your mind.
IS CBD RIGHT FOR YOU?
CBD oil is becoming a popular health supplement. You can use it as one of many natural-derived compounds aimed at enhancing the quality of life. But as it is the case for most natural compounds, the reaction to CBD is individual. You don’t know if it will improve your wellbeing and alleviate your problems until you try it.
To help you to make an informed choice, we suggest you read a few non-biased, not-for-profit sources such as Wikipedia and reputable medical sites.
Despite numerous studies of a wide variety of CBD dosages and ways of CBD application, no side effects have been reported.
HOW TO USE CBD
Irrespective of the uptake mode, a typical dosage of CBD oil would be 3-4 drops three times a day. According to a recent study, up to 160 mg/day orally is tolerated.
You can use CBD via most natural routes health supplements are taken into the organism. The most prevalent are through the skin and orally, which allow contact and uptake of biological substances.
*The simplest and most convenient method of CBD consumption is to pipette oil under the tongue where a lot of capillaries are located, allowing for rapid diffusion into the blood stream. CBD has a pleasant taste. If you are worried about using too much in one go, pipette the oil on a clean (essential!) hand and lick it. You can also pipette the oil on an absorbent food such as a piece of bread or your favourite biscuit and eat it.
*If you have a dermatological problem, your preferable way of using CBD oil will be applying CBD oil onto the damaged part of skin, although you may want to mix our concentrated oil with your favourite neutral lotion to reduce spillage and increase the contact area.
HOW DOES CBD WORK?
The human nervous system contains a large number of receptors. Receptors are like mobile telephone masts transmitting signals. But if a mobile mast accepts an electromagnetic wave as a signal, receptors use specific molecules to transmit messages.
One of the receptor systems is the so-called endocannabinoid system (ECS). ECS receptors are located in the human brain and in the peripheral nervous system – spinal cord and nerves. In the brain, the receptors reside in areas responsible for perception, concentration, memory and movement. That’s why the ECS is involved in the regulation of many physiological processes including the feeling of pain, mood, and appetite. Interestingly, the ECS is also a part of in neural system response to physical excise. “Runner’s high” is caused by ECS action.
The ECS receptors are CB1 and CB2, 5-HT1A, μ, and δ. The receptors bind cannabinoid-like molecules produced by the nervous system, endorphins. One of the endorphin molecules transmitting signals in the ECS is 2-Arachidonoylglycerol (2-AG). It binds to CB1 and CB2 receptors. Cannabidiol, CBD, also bind to these receptors and replicates the effects of 2-AG.
CBD binds to the same receptors as psychoactive THC but has an opposite effect. If THC gets your nervous system into overdrive CBD makes it slow down.
Therefore, using CBD containing oil is a good way of muscle and general relaxation.
THE BIOLOGY AND CHEMISTRY OF CBD
The wild Cannabis sativa plants produce a smorgasbord of organic compounds with THC and CBD among them. Just as other domesticated plants were selected to produce specific molecules in high quantities, Cannabis sativa has been selectively bred for different purposes. As a result of breeding, the original plant has been split into distinct cultivars with different qualities (think Brussel sprouts and cauliflower originated from wild brassica). Current “cannabis” cultivars focused on producing as much as possible of THC to the detriment of other useful compounds. On the other hand, “hemp” cultivars focused on the industrial use and bred it to produce high quantities of CBD at the detriment of THC.
Cannabinoids THC and CBD are closely related to plant-derived compounds terpenoids such as menthol, camphor, and curcuminoids from in turmeric and mustard seed. Terpenoids are a large class of organic molecules used extensively in traditional cuisine because of their aromatic qualities. They also play a prominent role in traditional herbal remedies.
THC and CBD are produced in the same biosynthesis pathway. In other words, they have the same precursor molecule, cannabigerolic acid, CBGA. When the precursor is available, an enzyme, THCS synthase makes an extra ether link and converts CBGA into THCA that after decarboxylation converts to THC. In the parallel pathway, CBDA synthase converts CBGA into CBD precursor, CBDA.